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A 2017 review summarised neuroprotective properties of silymarin in animal models, including: Reduction of amyloidogenic activity (relevant in Alzheimer's research) Anti-inflammatory action in nerve tissue Reduction of oxidative stress in the brain Possible positive effects on cognitive function Possible reduction of stroke risk Whether these effects can be achieved in humans at attainable concentrations of silymarin in particular whether sufficient quantities can cross the blood-brain barrier remains unclear

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SIRT1 promotes lipolysis in adipocytes via activation of the rate-limiting lipolytic enzyme ATGL [14]

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placebo in adults with type 2 diabetes and inadequate glycemic control with diet and exercise alone

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A Phase II study of STX-100 is also ongoing

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